micro block 4

only double stranded RNA:
Reovirus
only single stranded DNA:
parvo
RNA replicates in cytoplasm except:
influenza (ortho) and retro (HIV, host genome)
DNA replicates in nucleus except:
parvo
rotavirus
reovirus
F-O transmission, limited to GI tract, diarrhea
reovirus (only double stranded RNA)
only helical positive polarity RNA
coronavirus
positive polarity RNA:
calici, pico, hepe, flavi, toga, retro, corona
(call pico henry and flavi to go right now; corona)
negative polarity RNA:
paramyxo, arena, rhabdo, bunya, filo, orthomyxi

(FARBOP)

enveloped RNA:
flavi, toga, retro (+ polarity, icosahedral)
all the – polarity are enveloped: filo, arena, rhabdo, bunya, ortho, paramyxo)
naked RNA:
reo, calici, hepe, picororna
HIV
retrovirus
replicates in host genome
retro (enveloped +)
most common causes for aseptic meningitis
mumps, coxsackie, and echo
help C
flavi (enveloped +)
rubella
(german measles) toga
congenital rubella effects:
(toga) hearing loss and cataracts
live attenuated virus BAD for pregnant women
rubella (toga; + and enveloped)
SARS
corona (+, enveloped)
M protein, N protein and RNA complex
coronavirus (+, enveloped)
norwalk, cruise-ship diarrhea
calici (+, naked)
picorna viruses:
PERCH (all entero except rhino)
polio, echo, rhino, coxsackie, hep A)
paralysis (death of motor neurons)
poliomyelitis (picorno;+, naked)
poliomyelitis diseases:
poliomyelitis, aseptic meningitis and post-polio syndrome
(picorno; +, naked)
echovirus diseases:
aseptic meningitis (main cause) and hemorrhagic conjunctivitis)
(picorno; +, naked)
common cold
rhinovirus (only non-entero of picorno; +, naked)
coxsackievirus group A
1.herpangina (fever, sore throat, vesicles in oropharynx
2.hand-foot-and-mouth disease (vesicular rashes on those areas)
(picorno; +, naked)
coxsackie group B
1.pleurodynia (pleuritiy type chest pain) -> bornhelm disease
2. myocarditis (dilated cardiomyopathy)
3. pericarditis
coxsackie groups A and B both cause:
aseptic meningitis, URT, febrile illness, paresis
paramyxovirus diseases:
measles, mumps, resp. synctial virus (RSV) and parainfluenza virus
HA in paramyxviruses:
measles, mumps, parainfluenza
RSV –
NA in paramyxoviruses:
mumps, parainfluenza
measles and RSV –
fusion protein in paramyxoviruses:
ALL 4 have fusion protein
koplik’s spots
measles
encephalitis -> subacute sclerosing panencephalitis
(childhood) measles
orchitis, meningitis, pancreatitis
mumps
mumps initially URT infection spreads via
local lymph nodes -> blood stream to parotid gland, testes, ovaries, pancreas, meninges
RSV
bronchiolitis and pneumonia in infants
bronchiolitis
RSV and parainvluenza virus
croup in children (seal bark)
parainfluenza virus
orthomyxo HA for
attachment
orthomyxo NA for
release
influenza
orthomyxo
antigen drift and shift
influenza A (orthomyxo; helical enveloped – polarity RNA)
only antigenic drift
influenza B (orthomyxo; helical enveloped – polarity RNA)
associated w/ Reye’s syndrome and GBS
influenza (orthomyxo; helical enveloped – polarity RNA)
hantavirus
bunyavirus
ebola
filo
lassa fever virus
arena
animal bite transmission
rhabdo
rhabdo diseases;
rabies and encephalitis
rabies replication @ bite site receptors:
ACh
negi bodies
rabies (rhabdo, – polarity enveloped helical RNA)
throat spasms on swallowing (hydrophobia
rabies, (rhabdo, – polarity enveloped helical RNA)
Categories: Microbiology